Long-term survival for duodenal adenocarcinoma is inconsistent in the literature.
The biology of duodenal adenocarcinoma is poorly understood.
Dr Shoup and colleagues from Illinois reviewed their institution's experience of duodenal adenocarcinoma from 1984 to 2005.
Clinicopathologic data were analyzed.
The team evaluated overall survival was estimated using Kaplan-Meier curves with log-rank test.
|T4 tumor status favored long-term survival|
|American Journal of Surgery|
The research team reported that of the 52 patients, 35 underwent potentially curative surgery.
The team assessed 31 patients who survived the postoperative period.
Of these patients, the median survival was 34 months compared with 13 months for those not undergoing curative surgery.
The researchers found that clinicopathologic factors favoring long-term survival were tumor size more than 3.5 cm, and a T-stage of 4.
Dr Shoup's team concluded, “Clinicopathologic factors important to survival in duodenal cancer are T4 tumor status and tumor size.”
“Interestingly, larger tumors were less likely to be invasive, and patients with these tumors had improved survival.”
“The biology of this cancer is poorly understood.”
“Therefore, aggressive resection for all duodenal adenocarcinomas is recommended for all patients medically fit to undergo resection.”