Reported symptoms, esophageal pHmetry and proton pump inhibitor treatment are used for diagnosing gastro-esophageal reflux-related cough.
Weakly acidic reflux is now increasingly associated with reflux symptoms such as regurgitation or chest pain.
Dr Blondeau and colleagues from Belgium studied the association between weakly acidic reflux and cough in 100 patients with unexplained chronic cough.
The research team used impedance-pHmetry for reflux detection and manometry for objective cough monitoring.
Symptom Association Probability Analysis characterized the reflux-cough association.
|Impedance-pH-manometry identified cough related to reflux|
|Alimentary Pharmacology & Therapeutics|
The researchers found that acid reflux could be a potential mechanism for cough in 45 patients.
These patients had either heartburn, high acid exposure or a positive Symptom Association Probability analysis for acid reflux.
Weakly acidic reflux could be a potential mechanism for cough in 24 patients.
The team noted that these patients had either increased esophageal volume exposure, weakly acidic reflux or a positive Symptom Association Probability analysis.
Reflux could not be identified as a potential mechanism for cough in 31 patients.
Dr Blondeau's team concludes, “A positive association between cough and weakly acidic reflux was found in a significant subgroup of patients with unexplained chronic cough.”
“Impedance-pH-manometry identified patients in whom cough can be related to reflux that would have been disregarded using the standard diagnostic criteria for acid reflux.”