Microscopic colitis is a rare disease of unknown etiology.
It has been described that some drugs could cause or worsen the disease.
However, the scientific evidence is limited.
Dr Fernando Fernández-Bañares and colleagues from Spain investigated the possible association of chronic drug consumption with microscopic colitis.
The investigators inducted a case-control study.
The team evaluated 39 patients in Group 1 with collagenous colitis.
Groups 2 included 39 patients with lymphocytic colitis.
The investigators allocated a further 52 patients with chronic watery diarrhea of functional characteristics to Group 3.
The control group involved 103 subjects.
|46% in Group 1 consumed NSAIDs vs 23% of controls|
|American Journal of Gastroenterology|
At diagnosis, a drug consumption history of at least 2-week duration was registered.
An age- and sex-adjusted logistic regression analysis was used.
The investigators calculated the odds ratio, 95% confidence interval.
The investigators found that drug consumption occurred in 92% of the group with lymphocytic colitis vs 76% in control group.
The mean daily number of drugs by person was also higher in lymphocytic colitis.
The investigators observed that 46% of patients in Group 1 consumed non-steroidal anti-inflammatory drugs (NSAIDs) vs 23% in controls.
In Group 1, about 18% used selective serotonin reuptake inhibitors, specifically, sertraline.
In Group 2, about 28% used selective serotonin reuptake inhibitors, 13% used beta-blockers, 13% used statins, and 8% used biphosphonates.
The team noted that in Group 3, 15% used selective serotonin reuptake inhibitors, and 12% used statins.
In comparison, the investigators found that 23% of controls used NSAIDs, and 1% used selective serotonin reuptake inhibitors.
A further 3% of controls used beta-blockers, 3% used statins, 0% used biphosphonates.
As compared with the chronic diarrhea group, the team identified a significant association with the usage of sertraline in lymphocytic colitis.
The investigators observed a trend for use of NSAIDs in collagenous colitis.
Dr Fernández-Bañares' team concluded, “Drug consumption increases the risk of microscopic colitis.”
“Some drugs might be trigger factors of colonic inflammation in predisposed hosts, and others might only worsen self-evolving microscopic colitis.”