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 20 February 2018

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News

Circulating tumour cells predict colorectal cancer recurrence

Reverse transcriptase-polymerase chain reaction positivity within 24 hours of colorectal cancer resection predicts recurrence, finds this month's British Journal of Surgery.

News image

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Dr Allen-Mersh and colleagues assessed the potential for reverse transcriptase-polymerase chain reaction-based circulating tumor cells to predict colorectal cancer recurrence.

mRNA for carcinoembryonic antigen and cytokeratin 20 was identified by reverse transcriptase-polymerase chain reaction in patients with colorectal cancer,

The blood samples were taken before and after primary tumor resection.

Cancer recurrence was assessed at follow-up.

The team estimated the accuracy of reverse transcriptase-polymerase chain reaction, and primary tumor lymph node positivity in predicting recurrence.

The researchers studied 196 patients with colorectal cancer over a median follow-up of 1393 days from surgery.

There was a 50% recurrence risk in 48% of patients after resection
British Journal of Surgery

Regression analysis selected 24-hour post-resection reverse transcriptase-polymerase chain reaction positivity before lymph node involvement.

When 24-hour post-resection reverse transcriptase-polymerase chain reaction was combined with lymph node positivity, the hazard ratio increased.

The researchers noted that this attributed a 3% recurrence risk to 52% of patients with colorectal cancer resected with curative intent.

The team observed a 50% recurrence risk to 48% of patients with colorectal cancer resected with curative intent.

Dr Allen-Mersh's team concludes, “Reverse transcriptase-polymerase chain reaction positivity within 24 hours of primary colorectal cancer resection is a strong predictor of colorectal cancer recurrence, and may be useful clinically.”

Br J Surg 2007: 94(1): 96-105
19 January 2007

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