Recent evidence found probiotics could inhibit Helicobacter pylori colonization from both in vitro and in vivo studies.
Dr Ran and colleagues from China systematically evaluated whether adding probiotics to anti-H pylori regimens could improve eradication rates.
The research team also assessed whether this could reduce side effects during anti-H pylori treatment.
Eligible articles were identified by searches of electronic databases.
| Pooled H pylori eradication rates were 84% with probiotics|
|Alimentary Pharmacology & Therapeutics|
The researchers included all randomized trials comparing probiotics supplements to placebo or no treatment during anti-H pylori regimens.
The team performed statistical analysis with Review Manager 4.2.8.
In addition, the researchers undertook subgroup and sensitivity analysis.
The researchers identified 14 randomized trials involving 1671 subjects.
The team found that pooled H pylori eradication rates were 84% for patients with probiotics by intention-to-treat analysis.
For patients without probiotics, the pooled H pylori eradication rates by intention-to-treat analysis were 75%.
The team noted that the odds ratio was 1.8, and the occurrence of total side effects were 25% for groups with probiotics.
For groups without probiotics, the odds ratio was 0.4 with total side effects occurring in 39%.
Dr Ran's team concludes, “Our review suggests that supplementation with probiotics could be effective in increasing eradication rates of anti-H pylori therapy.”
“This could be considered helpful for patients with eradication failure.”
“Furthermore, probiotics show a positive impact on H pylori therapy-related side effects.”