Helicobacter pylori infection is a recognized cause of hypergastrinemia.
However, the association of blood gastrin levels with colonic adenomas is controversial.
Professor Spiros Ladas and colleages from Greece investigated if hypergastrinemia, H pylori infection and/or cagA protein are risk factors for colorectal adenomas.
The team of doctors collected fasting serum samples from 78 consecutive patients with colorectal adenomas in a prospective case-control study.
In addition, the doctors assayed 78 demographically matched colonoscopy-negative controls.
|H pylori infection was not an independent risk factor|
The team evaluated the samples for anti-H pylori immunoglobulin G, cagA protein and serum gastrin levels.
Multivariate analysis was performed to identify risk factors for colon adenomas.
The researchers observed that the prevalence of H pylori antibodies was not significantly different between the groups.
However, the prevalence of cagA protein was significantly higher in patients with adenomas as compared with controls.
The doctors noted that mediangastrin levels were significantly higher in patients with colorectal adenomas.
Hypergastrinemia was commoner in patients with colorectal adenomas than in controls.
The team found that hypergastrinemia was the only independent risk factor for adenomas.
H pylori infection or cagA positivity were not independent risk factors.
The doctors noted a significant association of hypergastrinemia and distal distribution of adenomas.
Professor Ladas' team concludes, “Our study shows that hypergastrinemia is a risk factor for colorectal adenomas, especially of the distal colon.”