Helicobacter pylori eradication fails in about 25% to 30% of children.
This failure is particularly because of the occurrence of resistance to antibiotics and side-effects.
Dr Francavilla and colleagues from Italy determined whether adding Lactobacillus reuteri to an anti-H pylori regimen prevents gastrointestinal side-effects in children.
The researchers treated 40 H pylori-positive children, of which 21 were males with a median age of 12 years.
|Gastrointestinal Symptom Rating Scale scores were reduced with probiotics|
|Alimentary Pharmacology & Therapeutics|
The patients were consecutively treated with 10-day sequential therapy.
Omeprazole plus amoxycillin was given for 5 days, followed by omeprazole plus clarithromycin with tinidazole for other 5 days.
The children were then blindly randomized to receive either L reuteri ATCC 55730 or placebo.
All children completed the Gastrointestinal Symptom Rating Scale at entry, during and after treatment.
The researchers assessed H pylori status after 8 weeks by 13C-urea breath test.
After probiotic supplementation compared with placebo, there was a reduction of Gastrointestinal Symptom Rating Scale score during eradication therapy.
The researchers found that the reduction was significant in probiotic supplemented children also at the end of follow-up.
The team observed that children receiving L reuteri reported less symptoms than those receiving placebo.
Dr Francavilla's team comments, “L reuteri is capable of reducing frequency and intensity of antibiotic-associated side-effects during eradication therapy for H pylori.