The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial.
Dr Jérôme Galon and colleagues from France characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers.
The investigative team undertook gene expression profiling and in situ immunohistochemical staining.
|Immune cell analysis better predicts survival than histopathological methods|
The team evaluated the type, density, and location of immune cells within the tumor samples.
Collectively, these data better predict patient survival than histopathological methods currently used to stage colorectal cancer.
The results were validated in 2 additional patient populations.
Dr Galon's team concludes, “These data support the hypothesis that the adaptive immune response influences the behavior of human tumors.”
“In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.”