Professor Alan Casson and colleagues from Canada examined the association of obesity with esophageal adenocarcinoma.
The research team also assessed the association of obesity with precursor lesions Barrett esophagus and gastroesophageal reflux disease (GERD).
The team conducted a case-control study included 142 cases with GERD, 130 with Barrett esophagus, and 57 with esophageal adenocarcinoma.
Controls comprised 102 asymptomatic individuals.
The researchers used logistic regression methods to compare obesity rates between cases and controls.
|Diets high in Vit C were associated with a lower GERD risk|
|Diseases of the Esophagus|
The team adjusted for differences in age, gender, and lifestyle risk factors.
Relative to normal weight, obese individuals were at increased risk for esophageal adenocarcinoma.
The researchers found that diets high in Vitamin C were associated with a lower risk for GERD, Barrett's, and esophageal adenocarcinoma.
For the more established risk factors, the team confirmed that smoking was a significant risk factor for esophageal adenocarcinoma.
Increased liquor consumption was associated with GERD and Barrett esophagus.
Professor Casson's team concludes, “In light of the current obesity epidemic, esophageal adenocarcinoma incidence rates are expected to continue to increase.”
“Successful promotion of healthy body weight and diets high in Vitamin C may substantially reduce the incidence of this disease.”