Dr Yasuo Egi and colleagues from Japan clarified the pathogenesis of gastric inflammation in the cardia.
The research team assessed 80 participants.
Biopsy specimens of the gastric antrum, corpus, and cardia were obtained, and histological gastritis was evaluated.
The team evaluated cardiac inflammation using magnifying gastroscopy.
The researchers examined Helicobacter pylori infection, gastric juice pH/bile acid, serum pepsinogen and gastrin levels.
|Cardiac inflammation was linked to low acid output|
|Digestive Diseases & Sciences|
Gastroesophageal reflux disease, and habitual smoking were also measured.
The team assessed the relations between these factors and cardiac inflammation.
The prevalence of H pylori infection was statistically higher in patients with cardiac inflammation than in those without inflammation.
The researchers demonstrated the relationship by magnifying gastroscopy.
Cardiac inflammation was linked to low acid output but not linked to the pH/bile acid concentration or habitual smoking.
The team noted that cardiac inflammation was more pronounced in patients without gastroesophageal disease.
Dr Egi's team concludes, “These results suggest that H pylori is a major risk factor for cardiac inflammation in the Japanese.”