Neuropsychiatric complications are an important source of morbidity following orthotopic liver transplantation.
Etiology of liver disease and type of immunosuppression are possible related factors.
Dr Claudio Tombazzi and colleagues from Tennessee described the prevalence of neuropsychiatric complications after liver transplantation.
The investigators explored the role of immunosuppression, and the association between these and specific liver diseases such as Hepatitis C.
The investigative team studied 128 patients with liver transplants.
|In 43 of 49 patients, the etiology was associated with immunosuppression|
|Digestive Diseases & Sciences|
Tacrolimus was the primary immunosuppressant in 101 patients and cyclosporine in 27 patients.
The team reported that 75 complications occurred in 49 patients.
In 43 patients, the etiology was associated with immunosuppression.
Of these, 36 were on tacrolimus and 7 on cyclosporine.
The investigators noted that 18% of patients with Hepatitis C and 5% of patients without Hepatitis C developed depression.
Dr Tombazzi's team commented, “There is no difference between types of primary immunosuppression and neuropsychiatric complications.”
“The investigative team observed a significantly greater incidence of depression in patients transplanted for Hepatitis C.”