Dr Helen Lydatakis and colleagues from Greece searched for a non-invasive marker to predict liver fibrosis without liver biopsy in non-alcoholic steatohepatitis.
The investigative team assessed 50 patients.
All patients had 1 or more conditions that characterize the metabolic syndrome and histological proven non-alcoholic steatohepatitis.
The team determined hyaluronic acid, leptin and laminin from serum withdrawn at the day of biopsy.
The investigators divided patients into 2 groups according to the histological findings.
|Laminin can be used to diagnose, but not stage fibrosis|
Group 1 consisted of 23 patients with non-alcoholic steatohepatitis and fibrosis.
Group 2 included 27 patients with non-alcoholic steatohepatitis, ballooned cells, without fibrosis.
The investigators found that subjects with non-alcoholic steatohepatitis and fibrosis had higher hyaluronic acid and laminin than those without fibrosis.
In contrast, the team noted no statistically significant difference between the levels of serum leptin in the 2 groups.
The stage of liver fibrosis in the 23 patients of group 1 was related only to the values of hyaluronic acid, and not to the ones of leptin and laminin.
Dr Lydatakis' team concludes, “Measurement of hyaluronic acid could be a predictive factor of the presence and stage of liver fibrosis in non-alcoholic steatohepatitis.”
“Laminin could be used to diagnose liver fibrosis but has no value in staging.”