Measuring Crohn's disease activity is useful in clinical trials as well as in clinical practice.
However, each available instrument to measure such activity has some limitations.
Dr Patrick Chamouard and colleagues from France assessed the diagnostic value of low level of C-reactive protein for predicting a low Crohn's disease activity.
The team of doctors calculated an optimal C-reactive protein cutoff value for selecting patients with moderate or high Crohn's disease activity.
The team included 150 consecutive patients with active or nonactive Crohn's disease without any pre-selection criteria.
|49% of the patients had C-reactive protein levels more than 20 mg/L|
|Clinical Gastroenterology & Hepatology|
C-reactive protein was measured, and Crohn's disease activity was calculated by means of the van Hees index.
The doctors found that the median van Hees index score was 154, and the median C-reactive protein was 19 mg/L.
The team of doctors noted that 49% of the patients had C-reactive protein levels more than 20 mg/L.
C-reactive protein was significantly correlated to van Hees index.
The probability that van Hees index was less than 150 if C-reactive protein was below upper limit of normal was equal to 1.
The team observed that the diagnostic value for C-reactive protein predicting a van Hees index of 150 was high.
The area under the receiver operating characteristic curve was equal to 0.8 with an optimal cutoff value of 21.6 mg/L, about 5 × N.
Dr Patrick Chamouard's team concluded, “C-reactive protein appears useful to evaluate Crohn's disease activity, especially to predict inactive or low activity Crohn's disease.”