Few data exist regarding exposures associated with colorectal cancer in patients with Crohn's colitis.
Drs Corey Siegel and Bruce Sands identified exposures that alter the risk of colorectal cancer in patients with Crohn's colitis.
The team of doctors used the Research Patient Database Registry at Massachusetts General Hospital to identify cases and controls.
Cases had a confirmed diagnosis of Crohn's disease involving at least a third of the colon and a confirmed diagnosis of colorectal adenocarcinoma.
The doctors randomly chose matched controls from the same source population.
Paired univariate analysis was performed to develop an odds ratio for each exposure.
The team found 27 patients to have Crohn's colitis and colorectal cancer .
Colonoscopy performed for screening or surveillance was associated with an odds ratio of 0.2.
|Smoking history was associated with a 4-fold-increased colorectal cancer risk|
|Inflammatory Bowel Diseases|
The team noted that prior appendectomy and regular 5-aminosalicylate use showed a nonsignificant trend for a protective effect.
Smoking history was associated with a 4-fold-increased risk for colorectal cancer, but this was not statistically significant.
Dr Siegel and colleague concluded, “We found that having a colonoscopy for an indication of surveillance or screening is associated with decreased risk of colorectal cancer in the setting of Crohn's colitis.”
“These data underscore the importance of colorectal cancer surveillance for Crohn's colitis in addition to ulcerative colitis and should prompt further study in this area.”