The potential of physical activity and/or weight control as a preventive and/or therapeutic option in the treatment of fatty liver diseases needs to be examined.
Dr Timothy Church and colleagues from Texas examined the association between cardiorespiratory fitness, body mass index, and waist circumference with markers of nonalcoholic fatty liver disease.
The participants of the team consisted of 218 apparently healthy nonsmoking, nonalcoholic men aged 33 to 73 years.
Cardiorespiratory fitness was assessed by a maximal treadmill test.
| Waist circumference attenuated the association with nonalcoholic fatty liver disease|
Liver and spleen density were measured using a computed tomography scan
The team defined the presence of nonalcoholic fatty liver disease as liver to spleen density of 1 or less, and serum alanine transaminase levels greater than 30 U/L.
Serum aspartate transaminase/alanine transaminase levels less than 1 also defined nonalcoholic fatty liver disease.
The research team recruited 24 of the participants, who met the nonalcoholic fatty liver disease definition.
The team found an inverse association between fitness categories.
A positive association with nonalcoholic fatty liver disease was observed with body mass index categories, and waist circumference categories.
Fitness and body mass index were factors independent of each other in their associations with the prevalence of nonalcoholic fatty liver disease.
The team noted that waist circumference attenuated the association with prevalence of nonalcoholic fatty liver disease for fitness and body mass index.
Dr Church's team concluded, “Fitness and body mass index were associated with the prevalence of nonalcoholic fatty liver disease.”
“However, these associations were attenuated when abdominal obesity was included in the statistical model.”