In this study, researchers from Taiwan examined the relationship between type 2 diabetes and primary hepatocellular carcinoma in countries with a high level of hepatitis infection.
The team followed a prospective cohort of 54,979 subjects who participated in the Keelung Community-Based Integrated Screening program between 1999 and 2002.
The researchers identified 5732 subjects with type 2 diabetes and 138 with hepatocellular carcinoma.
The team calculated the independent effect of type 2 diabetes on the incidence of hepatocellular carcinoma, and the interaction between diabetes and hepatitis infection or lipids profile.
After controlling for a number of factors the team found that the association was modified by HCV status and cholesterol level.
|The association was modified by HCV status and cholesterol level.|
They determined that in patients with type 2 diabetes, being HCV negative or having hypercholesterolemia increases the risk of liver cancer.
Dr Mei-Shu Lai's team concluded, "In an area with a high prevalence of hepatitis virus infection, type 2 diabetes increases the risk of developing hepatocellular carcinoma in those who are HCV negative or have a high level of total cholesterol".