In this study, researchers from Houston, Texas, evaluated gender differences in esophageal carcinoma patients treated with preoperative chemoradiotherapy.
They assessed presentation at baseline and therapy outcome.
|Carcinomas in women correlated with lower clinical N classification.|
|Diseases of the Esophagus|
The team stratified patients according to gender. They then compared pretreatment clinical stage, post- chemoradiotherapy effect on carcinoma in the resected specimen, overall survival, and patterns of failure.
The study included 235; 203 men and 32 women.
The researchers determined that carcinomas in women correlated with clinical stage II classification, while cancers in men correlated with clinical stage III classification.
Furthermore, carcinomas in women correlated with lower clinical N classification.
In addition, at a median follow-up of 37 months, 10% more women than men remained alive (63% vs 53%).
Distant metastases-free survival time was longer for women than men.
Dr Rohatgi's team concluded, "Our results suggest that localized esophageal carcinoma is diagnosed in more advanced stages in men than in women".
"The reasons for these differences remain unclear and further expansion of these observations and study of biologic differences that might exist are warranted".