Operative mortality for a right lobe donor in adult living donor liver transplantation is estimated to be as high as 1%.
To minimize the risk to the donor, left lobe-living donor liver transplantation might be an ideal option in adult living donor liver transplantation.
Dr Soejimaa and colleagues from Japan assessed the feasibility of left lobe-living donor liver transplantation between adults.
The researchers based the study on a single-center experience of 107 left lobe-living donor liver transplantations performed over 8 years.
|The 1-year survival rate in left lobe-living donor liver transplantation was 81%|
|American Journal of Transplantation|
The research team reported that the mean left lobe graft weight was 452g, which amounted to 41% of the estimated standard liver volume of the recipients.
The overall 1-, 3- and 5-year patient survival rates in left lobe-living donor liver transplantation were 81%, 77%, and 75%, respectively.
The team noted that these rates were comparable to those of right lobe-living donor liver transplantation.
The researchers reported that 24% of grafts were lost for various reasons, with 3 losses directly attributable to small-for-size graft syndrome.
Post-operative liver function and hospital stay in left lobe donors were significantly better and shorter than that in right lobe donors.
The research team found that the incidence of donor morbidity was comparable between left lobe and right lobe donors.
Dr Soejimaa's team commented, “Left lobe-living donor liver transplantation was found to be a feasible option in adult-to-adult living donor liver transplantation.”
“Further utilization of left lobe grafts should be undertaken to keep the chance of donor morbidity and mortality minimal.”