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 23 February 2018

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News

Endoluminal gastroplasty and polymer injections both improve GERD

EndoCinch™ and Enteryx™ are equally successful in treating GERD, by reducing the proton pump inhibitor dosages, and also improving symptoms of patients, reports March's American Journal of Gastroenterology.

News image

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Dr Dirk Domagk and colleagues from Germany compared the efficiency and safety of 2 new endoscopic antireflux procedures for treating gastroesophageal reflux disease (GERD).

The investigative team conducted a prospective, randomized trial, comparing endoluminal gastroplasty (EndoCinch™) with polymer injection (Enteryx™).

The team included 51 consecutive patients dependent on proton pump inhibitor therapy.

Follow-up evaluation included drug consumption, symptoms, quality-of-life scoring, endoscopy, and manometry.

The investigators also monitored pH, and documented of adverse events.

The team assigned 26 patients to EndoCinch™ treatment, and 23 patients received Enteryx™ implantation.

Esophageal acid reflux decreased by 5% in endoluminal gastroplasty treated patients
American Journal of Gastroenterology

The team reported that 2 patients dropped out before applying endoscopic therapy.

At 6 months, proton pump inhibitor therapy could be stopped.

Alternatively, dosage was reduced by 50% or less in 77% of EndoCinch-treated patients and in 87% of patients treated by Enteryx™ .

The investigators noted that the difference in both groups to their pre-interventional status was statistically significant.

Esophageal acid reflux decreased from 15% to 10% in EndoCinch-treated patients, and from 16% to 14% in patients treated by Enteryx™.

Heartburn symptom score, modified DeMeester score, gastrointestinal life quality index, and Short Form-36 physical health survey score improved in both groups.

The team found that about 25% of the patients in both groups required retreatment in an attempt to achieve symptom control.

Dr Dogmak's team commented, “This is the first prospective, randomized study directly comparing 2 endoscopic anti-GERD techniques.”

“EndoCinch™ and Enteryx™ seem to be equally successful in the treatment of GERD significantly reducing the proton pump inhibitor dosages, and also by improving symptoms of patients.”

“Both endoluminal antireflux procedures may be promising therapeutic options.”

“Long-term evaluation will have to show if the positive initial results can be maintained.”

Am J Gastroenterol 2006: 101(3): 422
31 March 2006

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