Dr Raymond Cross and colleagues from the USA assessed patients with Crohn's disease by race.
The research team evaluated the differences in perforating disease behaviour,
disease severity, and extraintestinal manifestations.
The team identified outpatients with Crohn's at the University of Maryland Gastroenterology Faculty Practice or the Baltimore Veterans Affairs Maryland Health Care System, from 1997 to 2005.
The researchers assessed age at diagnosis, disease behavior, disease location, need for surgery and extraintestinal manifestations.
| Ileocolonic disease was an independent risk factor for perforating disease behavior|
|Inflammatory Bowel Diseases|
The research team found that race was not associated with perforating disease behavior, or need for surgery.
Extraintestinal manifestations of Crohn's disease were also not associated with race.
White patients were significantly more likely to have ileal disease.
The team observed that African American patients were significantly more likely to have ileocolonic and colonic disease.
Age at diagnosis younger than 40 years, and ileocolonic disease were independent risk factors for perforating disease behavior.
Similarly, the team noted that age at diagnosis younger than 40, ileal disease, and ileocolonic disease were associated with the need for surgery.
The researchers identified that female gender, and a positive family history of Crohn's were associated with joint manifestations of the disease.
Dr Cross' team concluded, “We did not detect differences in disease behavior, severity, or joint extraintestinal manifestations by race.”
“Although African American patients were more likely to have ileocolonic or colonic disease, these factors did not affect disease behavior or severity.”