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 21 May 2018

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News

Extrapancreatic neoplasms high with papillary mucinous neoplasms

The latest issue of Archives of Surgery finds that intraductal papillary mucinous neoplasms are frequently associated with the development of extrapancreatic neoplasms.

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Dr Min-Gew Choi and colleagues conducted a retrospective study tertiary care referral center.

The research team reported that 61 patients underwent surgical resection for intraductal papillary mucinous neoplasms between 1993, and 2004.

The team examined 38 patients with mucinous cystic neoplasms and 50 patients with pancreatic ductal adenocarcinoma for extrapancreatic neoplasms.

The main outcome measures included the incidence and clinicopathological features of extrapancreatic neoplasms.

30% with intraductal papillary mucinous neoplasms had extrapancreatic malignancies
Archives of Surgery

The data of intraductal papillary mucinous neoplasms were compared with those with mucinous cystic neoplasm and pancreatic ductal adenocarcinoma.

The team noted that 39% of patients with intraductal papillary mucinous neoplasms developed 26 extrapancreatic neoplasms.

A further 30% with intraductal papillary mucinous neoplasms had extrapancreatic malignancies.

Gastric adenocarcinoma occurred in 33%, and colorectal adenocarcinoma in 17% were the most common neoplasms in the 24 patients.

During postoperative follow-up, 3 patients died of malignant intraductal papillary mucinous neoplasms.

Of these patients, 3 of associated malignancies, and 1 of a nonmalignancy-related cause.

There were no differences in age, sex, or family history of malignancy in patients with intraductal papillary mucinous neoplasms with and without associated malignancies.

The team also found no difference with history of cigarette smoking or alcohol abuse, or type of intraductal papillary mucinous neoplasms.

The incidence of extrapancreatic neoplasms in patients with intraductal papillary mucinous neoplasms was higher than in those with other pancreatic diseases.

The researchers observed that mucinous cystic neoplasm occurred in 8% of these patients, and pancreatic ductal adenocarcinoma occurred in 10%.

Dr Choi's team concluded, “Frequently, intraductal papillary mucinous neoplasms are associated with the development of extrapancreatic neoplasms.”

“Considerable attention should be paid to the possible occurrence of other associated malignancies in patients with intraductal papillary mucinous neoplasms, either concurrently or postoperatively.”

“Further molecular studies may be necessary to elucidate the unusual association between intraductal papillary mucinous neoplasms and other primary neoplasms.”

Arch Surg 2006: 141(1): 51-6
06 February 2006

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