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 25 May 2018

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News

Symptom diary for patients with GERD validated

The excellent psychometric properties of a simple gastro-esophageal reflux disease diary, reported by this month's Alimentary Pharmacology & Therapeutics, make it an attractive measure for future trials.

News image

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Symptom diaries are potentially attractive but, because of concerns about patient compliance, they have had limited use in clinical trials.

Dr Puhan and colleagues assessed the validity and responsiveness of a symptom diary with gastro-esophageal reflux disease (GERD).

The research team included 215 patients with gastro-esophageal reflux disease after starting treatment for 4 weeks with 40 mg esomeprazole once daily.

Patients recorded whether they experienced night-time heartburn.

The severity of daytime heartburn on a scale from 1 or no heartburn to 4 with severe heartburn as well as antacid use was recorded.

Daytime heartburn showed correlations with 4 scales of symptom severity for baseline scores
Alimentary Pharmacology & Therapeutics

Patients also completed a number of disease-specific and preference-based health-related quality of life questionnaires at baseline and follow-up.

Daytime heartburn showed moderate to strong correlations with the Quality of Life in Reflux and Dyspepsia questionnaire.

The team noted that daytime heartburn also showed correlations with 4 scales of symptom severity for baseline, follow-up and change scores.

Daytime heartburn had low correlations with the Standard Gamble.

The researchers observed that responsiveness of the daytime heartburn item was excellent with a mean change from baseline to follow-up of about −1.

The standardized response mean was just over 1 while responsiveness of the daily antacid use item was moderate.

Dr Puhan's team concluded, “The excellent psychometric properties of this simple gastro-esophageal reflux disease diary make it an attractive measure for future trials.”

Aliment Pharmacol & Ther 2006: 23(4): 531
02 February 2006

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