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 22 May 2018

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News

Lymphocytic gastritis healed after H pylori eradication

Research in the latest Alimentary Pharmacology & Therapeutics demonstrates that 1-week triple therapy to eradicate of H pylori completely resolves lymphocytic gastritis.

News image

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An association between Helicobacter pylori infection and lymphocytic gastritis has been postulated.

Dr Madish and colleagues assessed the long-term effect of H pylori eradication therapy on lymphocytic gastritis.

The investigative team conducted a double-blind, placebo-controlled, multicenter trial.

The team randomized 51 patients with lymphocytic gastritis to receive either 1-week triple therapy for eradication of H pylori or omeprazole plus placebo.

96% were healed at 12 months after triple therapy vs 54% with omeprazole/placebo
Alimentary Pharmacology & Therapeutics

Endoscopy and histology was performed at baseline and after 3 and 12 months.

Patients of the omeprazole/placebo group with persistent lymphocytic gastritis after 12 months received crossover open-label triple therapy.

The team applied intention-to-treat analysis.

The investigators revealed that lymphocytic gastritis healing occurred in 83% at 3 months after triple therapy vs 58% with omeprazole/placebo.

After 12 months, the healing rate of lymphocytic gastritis was significantly higher after triple therapy, at 96%, compared with omeprazole/placebo at 54%.

The team observed that all patients who received crossover triple therapy, showed healing of lymphocytic gastritis after further 12 months.

Dr Madish's team commented, “Our study demonstrates that 1-week triple therapy aiming at eradication of H pylori leads to a complete and long-lasting resolution of lymphocytic gastritis in the majority of patients.”

Aliment Pharmacol Ther 2006: 23(4): 473
31 January 2006

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