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 24 February 2018

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News

Oral glucose tolerance test predicts cirrhosis prognosis

This month's American Journal of Gastroenterology shows that oral glucose tolerance test is useful for evaluating the prognosis of cirrhosis, and diabetes mellitus is one of the most powerful independent negative predictor of survival.

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Dr Tsutomu Nishida and colleagues evaluated whether oral glucose tolerance test was useful in evaluating the prognosis of liver cirrhosis.

The investigative team enrolled 56 patients with liver cirrhosis in a prospective cohort study.

In all cases, glucose tolerance was diagnosed by a 75 g oral glucose tolerance test according to World Health Organization criteria.

The relationship of clinical variables to the cirrhosis-related prognosis was investigated using univariate and multivariate regression models.

Diabetes mellitus was diagnosed in 21 subjects, impaired glucose tolerance in 13 subjects, and normal glucose tolerance in 22 subjects.

The cumulative survival rates of patients with liver cirrhosis and normal glucose tolerance were 95% at 5 years.

The investigators found that the survival rates of liver cirrhosis and impaired glucose tolerance at 5 years was 69%.

Liver cirrhosis and diabetes mellitus at 5 years had a 57% survival rate
American Journal of Gastroenterology

Liver cirrhosis and diabetes mellitus at 5 years had a 57% survival rate.

The survival rates of patients with liver cirrhosis and diabetes mellitus significantly differed from those with normal glucose tolerance.

The team used univariate analysis to demonstrate that serum albumin, total bilirubin, and prothrombin activity were prognostic factors.

Child-Pugh scores, and glucose intolerance were also highly significant prognostic factors.

Multiple regression analysis yielded albumin and diabetes mellitus as the most powerful independent negative predictors of survival.

Dr Nishida's team concluded, “Oral glucose tolerance test appears to be useful for evaluating the prognosis of cirrhotic patients.”

Am J Gastroenterol 2006: 101(1): 70
23 January 2006

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