Dr Aufenacker and colleagues determined whether systemic antibiotic prophylaxis prevent wound infection after repair of abdominal wall hernia with mesh.
The research team undertook a systematic review of the available literature identified from multiple databases.
The researchers used the terms ‘hernia' and ‘antibiotic prophylaxis'.
The team included 8 randomized placebo-controlled trials of antibiotic prophylaxis in abdominal wall mesh hernia repair.
The included trials had explicitly defined wound infection criteria and a minimum follow-up of 1 month.
|Infection after groin hernia repair was 3% with placebo vs 2% with antibiotics|
|British Journal of Surgery|
The team used independent quality assessment and data extraction.
Data were pooled for meta-analysis using a random-effects model.
There were 2 papers on umbilical, incisional or laparoscopic hernias, and 6 concerning inguinal and femoral hernias that were suitable for meta-analysis.
The team found that the incidence of infection after groin hernia repair was 3% in the placebo group and 2% in the antibiotic group.
The researchers noted that antibiotic prophylaxis did not significantly reduce the incidence of infection, with an odds ratio of 0.5.
The number of deep infections was 6 in the placebo group and 3 in the antibiotic prophylaxis group, with an odds ratio 0.5.
Dr Aufenacker's team concluded, “Antibiotic prophylaxis does not prevent the occurrence of wound infection after groin hernia surgery.”
“More trials are needed for complete evidence in other areas of abdominal wall hernia.”