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 28 May 2018

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News

Obesity, diabetes and smoking increase pancreatic cancer risk

Results in December's issue of the British Journal of Cancer show positive relationships of overall obesity, abdominal adiposity, diabetes and smoking with risk of pancreatic cancer.

News image

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Dr Larsson and colleagues from Sweden examined risk factors and associations with pancreatic cancer.

The team assessed the association of body mass index, waist circumference, a history of diabetes, and cigarette smoking with pancreatic cancer.

The researchers followed-up 37,147 women and 45,906 men during 560,666 person-years in the Swedish Mammography Cohort and the Cohort of Swedish Men.

The team diagnosed 136 incident cases of pancreatic cancer.

The multivariate rate ratio of pancreatic cancer for obese women and men was 1.8 compared to those with a body mass index of 20 to 25 kg/m2.

The team noted that for a difference of 20 cm in waist circumference, the multivariate rate ratios were 1.3 among women and 1.7 among men.

Current smokers of 40 pack-years had a 5-fold elevated risk vs with never smokers
British Journal of Cancer

The researchers found that pancreatic cancer risk was associated with history of diabetes and cigarette smoking.

Current smokers of 40 pack-years had a 5-fold elevated risk compared with never smokers.

The team observed that the risk among past smokers approached the rate ratio for never smokers within 5 to10 years following smoking cessation.

Dr Larsson's team concluded, “Findings from this prospective study support positive relationships of overall obesity, abdominal adiposity, diabetes and smoking with risk of pancreatic cancer.”

Br J Canc 2005: 93: 1310-5
29 November 2005

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