The incidence of hepatocellular carcinoma in cirrhotic and noncirrhotic liver is increasing in the world.
This is probably because of the high prevalence of infections by Hepatitis B and C viruses.
There are numerous publications on hepatic resection.
However, prognostic factors for intrahepatic recurrence and survival are not well known for patients with Hepatitis C without cirrhosis.
Dr Laurent and colleagues treated 108 consecutive patients with Hepatitis C in noncirrhotic liver by hepatic resection in the past 18 years.
Clinical, biologic, and histopathologic parameters of these patients were collected.
|5-year disease-free and overall survival rates were 43% and 29%|
|Journal of the American College of Surgeons|
Risk factors for intrahepatic recurrence and prognostic factors for survival were evaluated by univariate and multivariate analyses.
The research team found that postoperative morbidity and mortality rates were 23% and 7%, respectively.
The team noted that the 3- and 5-year disease-free and overall survival rates were 55% and 43%, and 43% and 29%, respectively.
Blood transfusion, absence of tumor capsule, and daughter nodules were independently associated with overall survival.
However, the team observed that risk factors for recurrence included blood transfusion, and absence of tumor capsule.
Daughter nodules, and margin resection less than 10 mm were also found to be risk factors for recurrence.
Dr Laurent's team concludes, “In the treatment of Hepatitis C without cirrhosis, hepatectomy remains a safe and legitimate treatment.”
“However, longterm results are impaired by a high rate of early recurrence likely related to metastatic dissemination.”
“Only histopathologic factors related to the tumor are predictive of recurrence and overall survival.”