The effect of gastro-esophageal reflux (GERD) on sleep and sleep quality is highly controversial.
Dr Dimarino and colleagues determined the temporal relationship of abnormal objective sleep parameters to GERD during acid suppression.
The investigative team included 16 patients with self diagnosed sleep disorders with and without GERD determined by standardized questionnaires.
The investigators conducted polysomnography during esophageal pH monitoring before and after omeprazole.
The team reported that all reflux events were followed by a sleep arousal or awakening.
|Rapid eye movement sleep increased from 55 to 95|
|Alimentary Pharmacology & Therapeutics|
Nocturnal acid reflux events were not predicted by the Carlsson score.
The investigators noted that omeprazole reduced acid reflux-associated arousals from 12 to 2 and awakenings from 8 to 4.
Sleep efficiency improved from 70% to 82% in a small subset of subjects with decreased sleep.
The investigative team observed that rapid eye movement sleep increased from 55 to 95.
In addition, the team found that total sleep time increased from 294 to 346.
Apnoea, hypopnoea and hypoxaemia were not associated with reflux.
Dr Dimarino's team concludes, “In subjects with gastro-oesophageal reflux, sleep arousals and awakenings are closely related to acid reflux events.”
“Reflux-related arousals and awakenings are decreased by acid suppression.”
“Acid suppression in selected subjects with reflux events and reduced sleep efficiency is associated with increased total sleep time, rapid eye movement sleep and sleep efficiency.”