Professor Paul Rutgeerts and colleagues from Belgium previously diagnosed and reported on fatal astrocytoma in a 60-year-old man with Crohn's disease.
The patient was treated with natalizumab, a monoclonal antibody against 4 integrins.
|JC virus DNA was in the serum 3 months after natalizumab, and 2 months before the symptoms|
|New England Journal of Medicine|
The researchers have now reclassified it as JC virus-related progressive multifocal leukoencephalopathy.
Frozen serum samples analyzed by the team showed that JC virus DNA had appeared in the serum 3 months after open-label natalizumab monotherapy.
The team also identified the JC virus DNA 2 months before the appearance of symptomatic progressive multifocal leukoencephalopathy.
There was staining of the brain lesion for polyomavirus.
Profesesor Rutgeerts concludes, “This case report, along with 2 others, suggests that anti-4-integrin therapy can result in JC virus-induced progressive multifocal leukoencephalopathy.”