Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 18 February 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Long-term benefit with photodynamic therapy for Barrett's cancer

This month's Gastrointestinal Endoscopy reports excellent long-term results of photodynamic therapy with 5-aminolevulinic acid for high-grade intraepithelial neoplasia or mucosal cancer, offering it as an alternative to surgical esophagectomy and endoscopic resection.

News image

fiogf49gjkf04

Photodynamic therapy with 5-aminolevulinic acid has proven to be safe and effective in patients with early neoplasia in Barrett's esophagus.

However, long-term results in patients with high-grade intraepithelial neoplasia or with early cancer are still lacking.

Dr Oliver Pech and colleagues from Germany evaluated the efficacy of photodynamic therapy with 5-aminolevulinic acid.

The researchers analyzed the effect of this treatment on the survival of 66 patients with early Barrett's neoplasia.

The team applied 5-aminolevulinic acid orally calculated at 60 mg per kg body weight 4 to 6 hours before photodynamic therapy.

Protoporphyrin IX induced by oral administration of 5-aminolevulinic acid was used as the photosensitizer.

Disease-free survival in patients with high-grade intraepithelial neoplasia was 89%
Gastrointestinal Endoscopy

The research team maintained acid suppression in all patients.

The researchers reported that between 1996 and 2002, 667 patients with early neoplasia in Barrett's esophagus were referred for local endoscopic therapy.

The team noted that a total of 558 patients fulfilled the criteria for local endoscopic therapy.

However, only 66 patients with a mean age of 61 years were treated by photodynamic therapy.

The patients were separated into 2 groups, with 35 with high-grade intraepithelial neoplasia in Group 1 and 31 patients with early adenocarcinoma in Group 2.

The researchers reported that a total of 82 photodynamic therapies with 5-aminolevulinic acid were performed.

The team found that 34 of the 35 patients in Group 1 and all patients in group 2 achieved a complete response during a median follow-up period of 37 months.

The researchers observed 1 local recurrence in Group 1 and 10 in group 2.

The team noted that 7 patients died during follow-up, but that all deaths were not tumor related.

No major complications were observed.

The team noted that disease-free survival in patients with high-grade intraepithelial neoplasia was 89%, and, in for mucosal cancer, it was 68%.

The calculated 5-year survival was 97% in Group 1 and 80% in Group 2, but there occurred no death related to Barrett's neoplasia.

Dr Pech's team concluded, “This study shows excellent long-term results of photodynamic therapy with 5-aminolevulinic acid in patients with high-grade intraepithelial neoplasia or mucosal cancer.”

Photodynamic therapy with 5-aminolevulinic acid might be offered as an alternative to surgical esophagectomy and endoscopic resection, especially in cases with multifocal Barrett's neoplasia.”

Gastrointest Endosc 2005: 62(1): 24
18 July 2005

Go to top of page Email this page Email this page to a colleague

 16 February 2018 
Undetected celiac in the elderly
 16 February 2018 
Inflammatory bowel diseases are global diseases
 16 February 2018 
Fructans induce non-celiac gluten sensitivity
 15 February 2018 
Oral direct-acting antiviral treatment for Hep C virus genotype 1
 15 February 2018 
NSAIDS and GI damage
 15 February 2018 
Primary vs secondary surgery for the presence of lymph node metastasis
 14 February 2018 
Management of hemorrhoids in the USA
 14 February 2018 
Predicting adenoma detection rate
 14 February 2018 
Normal bowel frequency characterization in the USA 
 13 February 2018 
Prebiotics improve endothelial dysfunction
 13 February 2018 
Personalising treatment options for IBS
 13 February 2018 
Diagnostic criteria for a Rome IV functional gastrointestinal disorders
 12 February 2018 
Visceral hypersensitivity and functional GI disorders
 12 February 2018 
Depression and aggressive IBD
 12 February 2018 
Variability in interpretation of endoscopic findings impacts patient management
 09 February 2018 
Treatment of choice for anastomotic stricture in IBD
 09 February 2018 
PRO measurement information system 
 09 February 2018 
Overall disease severity indices for IBD
 08 February 2018 
Prediction of endoscopically active disease

 08 February 2018 
Steroid-refractory acute severe ulcerative colitis
 08 February 2018 
Decision aid used by IBD patients
 07 February 2018 
Ursodeoxycholic acid combined with bezafibrate for itching
 07 February 2018 
Change in microbiome in gastritis vs gastric carcinoma
 07 February 2018 
Colorectal cancer and primary sclerosing cholangitis-IBD
 06 February 2018 
Risk of death after liver transplantation
 06 February 2018 
Crohn’s disease vs refractory pouchitis
 06 February 2018 
Support for functional dyspepsia symptom diary
 05 February 2018 
Helicobacter spp influence on GI tract 
 05 February 2018 
No link found between severe reflux and all-cause mortality 
 05 February 2018 
Psychological distress in PPI non-responders
 02 February 2018 
Assessing psychosexual impact of IBD
 02 February 2018 
Decrease in overall mortality with cholera vaccination
 02 February 2018 
Diagnostic performance of fecal immunochemical tests
 01 February 2018 
Screening frequency with family histories of colorectal cancer
 01 February 2018 
IBD and sport participation
 01 February 2018 
Life with a stoma 
 31 January 2018 
Aprepitant and gastroparesis 
 31 January 2018 
Anesthesia risk in colonoscopy
 31 January 2018 
GED-0301 for Crohn's Disease
 30 January 2018 
Intestinal dysbiosis and allergic diseases in infants
 30 January 2018 
Fructans and IBS symptoms in children
 29 January 2018 
Dosing calculator for therapy optimization in IBD
 29 January 2018 
Glecaprevir–pibrentasvir for in HCV
 29 January 2018 
Food allergen injections in eosinophilic esophagitis
 29 January 2018 
Reliability of the IBD index
 26 January 2018 
Tofacitinib vs biological therapies for ulcerative colitis
 26 January 2018 
Optimizing selection of biologics in IBD
 26 January 2018 
Nutritional risk and laparoscopic-assisted gastrectomy outcomes
 25 January 2018 
Patient-reported outcome measure for functional dyspepsia
 25 January 2018 
Predicting intra-abdominal infections after colorectal surgery
 25 January 2018 
Predictors of gastric cancer risk
 24 January 2018 
Risk factors underlying previously undiagnosed cirrhosis
 24 January 2018 
Ethnicity influences phenotype in IBD
 24 January 2018 
Bariatric surgery vs medical obesity treatment
 23 January 2018 
Atrophic gastritis after H. pylori eradication
 23 January 2018 
Ectopic pregnancy in women with IBD
 23 January 2018 
Celiac disease in IBS in the USA
 22 January 2018 
Improving symptoms in GERD
 22 January 2018 
Costs of biologic therapies for IBD in the USA
 22 January 2018 
Western vs Asian guidelines for colon cancer management

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us