Recent literature has shown a correlation between Crohn's disease and celiac disease, but a prospective study has not been performed.
Dr Antonio Tursi evaluated the prevalence of celiac disease in a consecutive series of patients affected by Crohn's.
The researchers analyzed patients in whom the disease was diagnosed for the first time.
|Antigliadin antibody tests were positive in 30% of patients|
|Inflammatory Bowel Diseases|
The research team diagnosed 27 patients affected by Crohn's in 2004, of which 13 were men and 14 were women with a mean age of 32 years.
In all patients, the researchers performed antigliadin, antiendomysium, and antitransglutaminase antibody tests, and the sorbitol H2 breath test evaluation.
In case of antibodies and/or sorbitol positivity, the team performed esophagogastroduodenoscopy for a small bowel biopsy.
The researchers found that antigliadin, antiendomysium, and antitransglutaminase antibody tests were positive in 30%, 15%, and 19% of patients, respectively.
The team observed that the sorbitol H2 breath test was positive in 41% of patients, and reported that all of them underwent esophagogastroduodenoscopy.
The research team noted that 9 of 11 patients showed signs of duodenal endoscopic damage, and 5 of 9 showed histologic features of celiac disease.
The team also reported that 2 showed Marsh IIIc lesions, of which 1 patient was affected by ileal Crohn's disease and 1 affected by ileo-colonic Crohn's disease.
In addition, the team found that 2 showed Marsh IIIb lesions, and both were affected by ileo-colonic Crohn's disease.
Only 1 patient showed a Marsh IIIa lesion, and was affected by colonic Crohn's disease.
Dr Tursi's team concludes, “Prevalence of celiac disease seems to be high among patients affected by Crohn's disease.”
“This finding should be kept in mind at the time of the first diagnosis of Crohn's, and a gluten-free diet should be promptly started.”