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 22 May 2018

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News

Early heartburn relief with proton pump inhibitors

Complete heartburn relief for the entire day occurs in 30% of patients after their first PPI dose, although most patients will not have symptom relief with 1 or 2 days of PPI therapy, reports June's issue of Clinical Gastroenterology & Hepatology.

News image

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Proton pump inhibitors (PPIs) are often taken for short-term treatment of heartburn.

Dr McQuaid and Dr Laine from California performed a systematic review of the efficacy of PPIs for heartburn relief within the first 1 to 2 days of therapy.

The researchers searched bibliographic databases for clinical trials of PPIs in patients with heartburn.

Meta-analyses was performed on 18 randomized trial comparisons of PPIs
Clinical Gastroenterology & Hepatology

The team looked for clinical trials that provided information about the proportion with heartburn relief at day 1 to 2.

The research team calculated the sample size-weighted pooled proportions of patients with complete or sustained relief for 7 consecutive days.

The researchers also performed meta-analyses of randomized comparisons of PPIs.

The team reported that 18 trials met the inclusion criteria.

The researchers found that at day 1 of PPI therapy, complete 24-hour, daytime, nighttime, and sustained heartburn relief occurred in 0.3, 0.5, 0.6, and 0.2 of patients.

The team observed that up to 37% of the heartburn relief achievable with 28 days of PPIs occurred on day 1.

Placebo was significantly less effective than PPIs for 24-hour relief on day 1, and single-dose PPI therapy was less effective than double-dose therapy.

Dr McQuaid and colleague concludes, “Complete heartburn relief for the entire day occurs in approximately 30% of patients after their first PPI dose and 9% of patients after their first placebo.”

“Although PPIs might provide benefit from the first day of therapy, most patients will not have symptom relief with 1 or 2 days of PPI therapy.”

Clin Gastroenterol Hepatol 2005: 3(6): 553
22 June 2005

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