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 20 February 2018

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News

5-Aminosalicylate protects against colorectal cancer and dysplasia

Pooled analyses in June's American Journal of Gastroenterology support a protective association between 5-aminosalicylates and colorectal cancer or a combined endpoint of colorectal cancer/dysplasia.

News image

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Dr Velayos and colleagues from California performed a systematic review with metaanalysis.

The team evaluated observational studies on the association between 5- aminosalicylate use and colorectal cancer or dysplasia among patients with ulcerative colitis.

The research team conducted a search of Medline, Embase, Biosis, Web of Science, Cochrane Collaboration, reviewed the literature, and consulted with experts.

The researchers included studies if they clearly defined exposure to 5-aminosalicylates in patients with ulcerative colitis.

5-Aminosalicylates use was not associated with a lower risk of dysplasia
American Journal of Gastroenterology

The team also included studies that reported colorectal cancer or dysplasia outcomes, that reported relative risks or provided data for their calculations.

Quantitative analysis using a random-effects model was used.

The researchers reported that 9 containing 334 cases of colorectal cancer, 140 cases of dysplasia, and a total of 1932 subjects satisfied all inclusion criteria.

The team found that 5 studies reported colorectal cancer outcomes alone, 2 studies reported separate cancer and dysplasia outcomes.

The researchers reported that 2 studies combined outcomes of colorectal cancer or dysplasia.

All primary estimates were homogenous.

With pooled analysis, the team showed a protective association between use of 5-aminosalicylates and colorectal cancer.

The team also observed a protective association between use of 5-aminosalicylates and a combined endpoint of colorectal cancer/dysplasia.

The researchers found that 5-aminosalicylates use was not associated with a lower risk of dysplasia, although only 2 studies evaluated this outcome.

Dr Velayos' team concluded, “Pooled results of observational studies support a protective association between 5-aminosalicylates and colorectal cancer or a combined endpoint of colorectal cancer/dysplasia in patients with ulcerative colitis.”

“Additional studies analyzing the effect of 5-aminosalicylates on risk of dysplasia are needed.”

Am J Gastroenterol 2005: 100(6): 1345
15 June 2005

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