The functional integrity of the intestinal epithelial barrier forms a major defense against invading pathogens, including gastrointestinal-dwelling nematodes.
|Epithelial cell movement rate is under immune control by cytokine interleukin-13 and chemokine CXCL10|
Pathogens are ubiquitous in their distribution worldwide.
In this study, Dr Laura Cliffe and colleagues show that an increase in the rate of epithelial cell turnover in the large intestine acts like an ‘epithelial escalator'.
This epithelial escalation expels Trichuris.
The researchers also found that the rate of epithelial cell movement is under immune control by the cytokine interleukin-13 and the chemokine CXCL10.
Dr Cliffe and colleagues concluded, “This host protective mechanism against intestinal pathogens has implications for our wider understanding of the multifunctional role played by intestinal epithelium in mucosal defense.”