Dr Magnus Nilsson and colleagues from Sweden examined the proposed relation between gastroesophageal reflux disease (GERD) and cancers of the larynx and pharynx.
|During follow-up, 30 cases of laryngeal and 31 cases of pharyngeal cancer were detected|
|Cancer Epidemiology Biomarkers and Prevention|
The researchers identified a cohort of 66,965 patients with discharge diagnoses of heartburn, hiatal hernia, or esophagitis in the Swedish Inpatient Register.
The research team observed a total of 376,622 person-years in the cohort.
The team achieved the identification of laryngeal and pharyngeal cancers through the Swedish Cancer Register.
The researchers used standardized incidence ratios, the ratio of the observed to the expected number of cancers, derived from the general Swedish population and adjusted for sex, age, and calendar year, to estimate the relative risk.
The investigators reported that during follow-up, 30 cases of laryngeal and 31 cases of pharyngeal cancer were detected in the cohort.
The researchers observed a slightly increased risks of laryngeal and pharyngeal carcinomas in the total reflux cohort.
After stratification to exclude cohort members with a diagnosis of alcoholism, the team found no significant increase in the risk of laryngeal or pharyngeal carcinomas compared with the general population.
Furthermore, the investigators noted that there were no dose-response patterns of the risk for laryngeal and pharyngeal cancers with years of cohort follow-up, indicators of reflux severity, or specificity of reflux diagnosis.
Dr Nilsson's team concluded, “This study provides no evidence in support of the proposed association between gastroesophageal reflux disease and cancers of the larynx or pharynx.”