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 22 May 2018

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News

Liver disease is a major cause of death in HIV and Hepatitis co-infections

Liver disease a leading cause of death among HIV-Hepatitis C co-infected patients and increasing among HIV-Hepatits B co-infections, with the highest risk in infections with both Hepatitis C and Hepatitis B, finds the most recent issue of the Journal of Hepatology.

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Dr Salmon-Cerona and colleagues analyzed the characteristics of HIV infected patients who died from liver disease, focusing on hepatitis virus co-infection.

The research team reported that 185 French hospital departments involved in HIV/AIDS management prospectively notified all deaths occurring in 2000.

The team classified patients whose Hepatitis C and Hepatitis B serostatus was known.

The main causes of death for HIV-Hep C co-infections is liver disease at 31%
Journal of Hepatology

The researchers classified the patients into 4 groups as being infected by Hepatitis C alone, Hepatits B alone, both Hepatitis C and Hepatitis B, or neither.

The team found that among 822 HIV infected patients, 29% were infected by Hepatitis C alone, 8% by Hepatitis B alone, and 4% by both Hepatits C and Hepatitis B.

The researchers noted that the most frequent causes of death were liver disease at 31% of cases and AIDS at 29% among HIV–Hepatitis C co-infected patients.

The team observed that the causes of death among HIV-Hepatitis B co-infected patients were AIDS at 38% and liver disease at 22%.

Liver disease was a more frequent cause of .death among patients co-infected by both Hepatitis C and Hepatitis B with 44% of cases.

The research team reported that hepatocellular carcinoma was present in 15% of patients who died from liver disease, and was associated with Hepatitis B co-infection.

Nearly half the patients who died from liver disease had more than 200 CD4/mm3.

Dr Salmon-Cerona concludes, “Liver disease is now a leading cause of death among HIV-Hepatitis C co-infected patients and is becoming an important cause of death among HIV-Hepatits B co-infected patients.”

“The risk of death from liver disease is highest in patients co-infected by both Hepatitis C and Hepatitis B.”

J Hepatol 2005: 42(6): 799
16 May 2005

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