Pyogenic liver abscess is a life-threatening disease and accurate data on incidence and prognosis are important, but scarce.
Dr Jepsen and colleagues examined changes in the incidence and 30-day mortality rate of patients with pyogenic liver abscess in Denmark.
Using nationwide administrative registers, the researchers identified all patients diagnosed with pyogenic liver abscess in Denmark, from 1977 to 2002, and their dates of death.
The researchers computed annual standardized incidence and 30-day mortality rates.
The team used Poisson regression to adjust gender-specific mortality rates for year by year differences in age at diagnosis.
|The cumulative 30-day mortality rate was 15% for men and 23% for women|
|Alimentary Pharmacology and Therapeutics|
The research team identified 1448 patients with pyogenic liver abscess, of whom 54% were men.
The crude incidence rate for the entire study period was 12 per 1 000 000 for men and 10 per 1 000 000 for women.
The researchers noted that between 1977 and 2002, the incidence rate increased from 6 to 18 per 1 000 000 for men and from 8 to 12 per 1 000 000 for women.
The cumulative 30-day mortality rate was 15% for men and 23% for women.
The team reported that the adjusted 30-day mortality rate decreased from 40% for men and 50% for women to around 10% for both genders.
Dr Jepsen’s team concludes, “In this large nationwide study spanning a 26-year period, we found an increasing incidence rate and a decreasing mortality rate of pyogenic liver abscess.”
“We believe that these changes are primarily explained by more sensitive diagnostic tools.”