Eradication of Helicobacter pylori is expected to prevent the development of gastric cancer.
However, gastric cancer is sometimes discovered after successful eradication of H pylori.
Dr Kamada and colleagues from Japan conducted a prospective study to determine the clinical features of patients who underwent successful eradication and were later diagnosed with gastric cancer.
| Gastric cancer occurred at a rate of 1 % during the follow-up period|
|Alimentary Pharmacology and Therapeutics|
The investigative team included a total of 1787 patients of which 1299 were males and 488 were females with a mean age of 58 years.
The patients underwent successful eradication therapy between 1994 and 2001.
The researchers found that gastric cancer occurred at a rate of 1 % during the follow-up period.
The investigators reported that gastric cancer occurred in 6 % of patients with early gastric cancer after endoscopic resection.
The research team observed that 2 % had gastric ulcer and 0.4 % presented with atrophic gastritis.
The team noted that gastric cancer did not develop in any patient with duodenal ulcer.
All patients with gastric cancer had baseline severe atrophic gastritis in the corpus.
Dr Kamada’s team concludes, “Careful endoscopic examination is necessary even after successful eradication of H pylori in patients with early gastric cancer or gastric ulcer with severe mucosal atrophy in the corpus.”