Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 25 February 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Pancreatic cell transplant from living donor could treat diabetes

A woman's diabetes has successfully been reversed by transplanting islets from a living donor's pancreas to her, reports the first successful study of its kind and published by The Lancet today.

News image

fiogf49gjkf04

A rising demand for islet transplantation will lead to severe donor shortage in the near future, especially in countries where cadaveric organ donation is scarce.

Since the success of islet transplantation in 2000 from the organs of dead donors, demand for the procedure has risen substantially and donors will soon be in very short supply.

Islet transplantation from living donors represent an alternative approach to expand the potential donor pool, particularly in countries like Japan where the number of people donating their organs after death is low.

2 previous attempts at transplantation from living donors have been carried out in the US but were unsuccessful.

Dr Shinichi Matsumoto and colleagues from Japan undertook a successful transplantation of living-donor islets for unstable diabetes.

The donor was a 56 year old woman who was also the mother of the recipient.

The researchers reported that the donor had a compatible blood group and also had healthy glucose and insulin concentrations.

The research team informed that the recipient was a 27 year old woman who had developed insulin-dependent diabetes when she was 15 years old.

The patient became insulin-independent 22 days after the transplantation
The Lancet

The investigators noted that the recipient had been admitted to hospital to control her frequent hypoglycaemic episodes, when her blood sugar levels dropped below normal.

The recipient received insulin injections every day in hospital.

The investigative team isolated islet cells from the donor and transplanted them into the recipient’s liver at Kyoto University Hospital in January 2005.

The researchers monitored the patient’s blood glucose after the operation and gradually weaned her off the insulin.

The investigators reported that the patient became insulin-independent 22 days after the transplantation and has been insulin independent for 2 months

The donor had no complications and both women have a healthy tolerance to glucose.

The investigators state that islets from living donors are more viable and more likely to function properly compared to islets from organs of dead donors.

The researchers derived the transplant cells from half of a living pancreas and reported a similar effect to that achieved from cells of 2 or more whole pancreases from dead donors.

The research team suggests that the difference in organ requirements indicate that improved potency of islets from living donors.

Dr Matsumoto concludes "From our successful transplantation of living-donor islets for treating unstable diabetes, our recipient achieved and maintained insulin dependence after procedure."

“Transplantation of living-donor islets from the distal pancreas can be sufficient to reverse brittle diabetes and be an additional option for the treatment thereof.”

In an accompanying comment, Dr Stephanie Amiel from the UK, states that, "In Japan, cultural considerations restrict the use of cadaveric donors."

"For patients with crippling hypoglyceamia in such societies, the only realistic donor would be a living donor."

"Islet transplant is not yet a perfect technique and insulin is only likely in the very insluin sensitive."

Lancet 2005 : Embargo, 00:01H (LT) April 19, DOI 10.1016/S0140-6736(05)66383-0
19 April 2005

Go to top of page Email this page Email this page to a colleague

 23 February 2018 
Patients on antithrombotic agents undergoing emergency and elective endoscopy
 23 February 2018 
Heavy metals on a gluten-free diet
 23 February 2018 
MRI and NAFLD
 22 February 2018 
Outcomes with Crohn’s after infliximab withdrawal
 22 February 2018 
Elderly onset of IBD

 22 February 2018 
Autophagy enhancers
 21 February 2018 
Management of hemorrhoids in the USA
 21 February 2018 
Adalimumab and infliximab in biologic-naïve Crohn's
 21 February 2018 
Cystic fibrosis and colorectal cancer
 20 February 2018 
Complications and surveillance colonoscopies
 20 February 2018 
Treatment algorithm for polyp cancers
 20 February 2018 
Predictors of postoperative infection in Crohn's
 19 February 2018 
Screening colonoscopy in the right and left colon
 19 February 2018 
NAFLD prevalence in the USA
 19 February 2018 
Fructans in children with IBS

 16 February 2018 
Inflammatory bowel diseases are global diseases
 16 February 2018 
Undetected celiac in the elderly
 16 February 2018 
Fructans induce non-celiac gluten sensitivity
 15 February 2018 
NSAIDS and GI damage
 15 February 2018 
Oral direct-acting antiviral treatment for Hep C virus genotype 1
 15 February 2018 
Primary vs secondary surgery for the presence of lymph node metastasis
 14 February 2018 
Predicting adenoma detection rate
 14 February 2018 
Normal bowel frequency characterization in the USA 
 13 February 2018 
Personalising treatment options for IBS
 13 February 2018 
Prebiotics improve endothelial dysfunction
 13 February 2018 
Diagnostic criteria for a Rome IV functional gastrointestinal disorders
 12 February 2018 
Visceral hypersensitivity and functional GI disorders
 12 February 2018 
Depression and aggressive IBD
 12 February 2018 
Variability in interpretation of endoscopic findings impacts patient management
 09 February 2018 
Treatment of choice for anastomotic stricture in IBD
 09 February 2018 
PRO measurement information system 
 09 February 2018 
Overall disease severity indices for IBD
 08 February 2018 
Prediction of endoscopically active disease

 08 February 2018 
Steroid-refractory acute severe ulcerative colitis
 08 February 2018 
Decision aid used by IBD patients
 07 February 2018 
Ursodeoxycholic acid combined with bezafibrate for itching
 07 February 2018 
Change in microbiome in gastritis vs gastric carcinoma
 07 February 2018 
Colorectal cancer and primary sclerosing cholangitis-IBD
 06 February 2018 
Risk of death after liver transplantation
 06 February 2018 
Crohn’s disease vs refractory pouchitis
 06 February 2018 
Support for functional dyspepsia symptom diary
 05 February 2018 
Helicobacter spp influence on GI tract 
 05 February 2018 
No link found between severe reflux and all-cause mortality 
 05 February 2018 
Psychological distress in PPI non-responders
 02 February 2018 
Assessing psychosexual impact of IBD
 02 February 2018 
Decrease in overall mortality with cholera vaccination
 02 February 2018 
Diagnostic performance of fecal immunochemical tests
 01 February 2018 
Screening frequency with family histories of colorectal cancer
 01 February 2018 
IBD and sport participation
 01 February 2018 
Life with a stoma 
 31 January 2018 
Aprepitant and gastroparesis 
 31 January 2018 
Anesthesia risk in colonoscopy
 31 January 2018 
GED-0301 for Crohn's Disease
 30 January 2018 
Intestinal dysbiosis and allergic diseases in infants
 30 January 2018 
Fructans and IBS symptoms in children
 29 January 2018 
Dosing calculator for therapy optimization in IBD
 29 January 2018 
Glecaprevir–pibrentasvir for in HCV
 29 January 2018 
Food allergen injections in eosinophilic esophagitis
 29 January 2018 
Reliability of the IBD index
 26 January 2018 
Tofacitinib vs biological therapies for ulcerative colitis

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us