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 21 May 2018

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News

Omeprazole in GERD does not lead to anti-gastric autoantibody production

The latest issue of Alimentary Pharmacology and Therapeutics finds that long-term acid suppression therapy in H. pylori-infected gastro-esophageal reflux disease patients does not increase or accelerate gastric autoimmunity.

News image

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Helicobacter pylori-associated atrophy of the gastric corpus is associated with the presence of anti-canalicular autoantibodies.

Also, long-term profound acid suppression in H. pylori-infected subjects may cause atrophic corpus gastritis.

Dr Bergman and colleagues investigated whether long-term acid suppression by omeprazole leads to antigastric autoantibodies.

1 patient developed an anti-canalicular antibody response during therapy
Alimentary Pharmacology and Therapeutics

The researchers treated 50 patients, of which 34 were H. pylori-positive on entry of the study, with 20 to 40 mg omeprazole once daily for reflux esophagitis.

The research team evaluated the patients for anti-gastric autoantibody responses by immunohistochemistry before and after treatment.

The team did not eradicate H. pylori and patients were followed for an average of 7 years.

In addition to immunohistochemistry, anti-H+, K+-ATPase reactivity was assessed by Western blot in paired sera of 41 patients, of which 26 were H. pylori-positive and 15 uninfected.

Results were critically evaluated by the team.

The investigators reported that in immunohistochemistry, most patients were negative for anti-canalicular autoantibodies when omeprazole therapy started.

Only 2 patients with corpus-predominant gastritis in the presence of H. pylori were not negative for anti-canalicular autoantibodies when omeprazole therapy started.

The research team also observed that 1 patient, who was H. pylori-negative, had newly developed an anti-canalicular antibody response during therapy.

Dr Bergman’s team concluded, “Our results indicate that, as compared with non-infected patients, long-term profound acid suppression therapy in H. pylori-infected gastro-esophageal reflux disease patients does not increase or accelerate gastric autoimmunity.”

Aliment Pharm Ther 2005: 21(8): 977
11 April 2005

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