Accurate preoperative prediction of the prognosis of patients with invasive ductal carcinoma of pancreatic head (pancreatic head cancer) is important for selecting treatment methods.
Dr Bunzo and colleagues retrospectively examined the prognostic predictive values of endoscopic ultrasound findings for patients with this disease.
The researchers included 66 patients with pancreatic head cancer who had undergone endoscopic ultrasound.
|Main pancreatic duct dilatation was an independent prognostic predictor by multivariate analysis|
The research team examined each endoscopic ultrasound finding as a possible prognostic predictor, including heterogeneity of internal echo, irregularity of peripheral echo and clarity of boundary echo.
In addition the team also examined dilatation of the main pancreatic duct, dilatation of the common bile duct, lymph node swelling, vessel invasion, and the presence of ascites, by univariate and multivariate analysis for survival.
The investigators found that irregular peripheral echo, portal vein invasion, superior mesenteric artery/celiac artery invasion, and the presence of ascites were significant predictors of a poorer prognosis by univariate analysis for survival.
In resectable cases, endoscopic ultrasound findings of main pancreatic duct dilatation and portal invasion were significant prognostic predictors by univariate analysis.
The researchers also showed that main pancreatic duct dilatation was an independent prognostic predictor by multivariate analysis in respectable cases
Dr Bunzo’s team concluded; “Endoscopic ultrasound may be useful for predicting the prognosis of patients with pancreatic head cancer, based on the accuracy it provides in evaluating locoregional spreading.”