Helicobacter pylori infection is a major cause of peptic ulcer disease and gastric cancer.
Dr Wei-cheng You and colleagues postulated that cranberry juice would be effective in the suppression of H Pylori in an endemically infected population at high risk for gastric cancer.
The investigative team conducted a prospective, randomized, double-blind, placebo-controlled trial in Linqu County of Shandong Province, China.
The researchers randomly divided 189 adults, with a mean age of 49 years, with H Pylori infection into two groups receiving cranberry juice (n = 97) or placebo (n = 92).
|The 13C-urea breath test was used to determine the degree and assess the alleviation of infection|
Participants were assigned by the research team to orally receive 2 x 250-ml juice boxes of cranberry juice or matching placebo beverage daily for 90 days.
The investigators determined the degree of H Pylori infection by using the 13C-urea breath test before randomization at 35 and 90 days of intervention to assess the efficacy of cranberry juice in alleviating infection.
A total of 189 subjects with positive 13C-urea breath test results prior to randomization completed the study.
The researchers reported that at day 35 of intervention, 14 of the 97 (14%) from the cranberry juice treatment group and 5 of the 92 (5%) of the placebo recipients had negative 13C-urea breath test results.
After 90 days, the team concluded that 14 of the 97 subjects in the cranberry juice treatment group versus 5 of the 92 in the placebo group yielded negative test results.
In addition, 11 individuals from the cranberry juice treatment group and only 2 from the placebo group were shown to be significantly negative at 35 and 90 days of the experiment.
Dr Wei-cheng You concludes, “Regular consumption of cranberry juice can suppress H Pylori infection in endemically afflicted populations.”