Since primary biliary cirrhosis is usually diagnosed in postmenopausal women with minor cholestasis, it has been questioned whether primary biliary cirrhosis itself represents a further risk for osteoporosis.
Dr Guañabensa and colleagues from Spain assessed the prevalence and risk factors for osteoporosis in an unselected series of women with primary biliary cirrhosis.
The investigators included 142 women with primary biliary cirrhosis (mean age: 54 years) and an age-matched control group.
|Age, Mayo risk score, body mass index and histological stage are independent risk factors for oteoporosis|
|Journal of Hepatology|
The researchers established osteoporosis by densitometry (bone mineral density below −2.5 T-score).
Age, duration and severity of primary biliary cirrhosis, body mass index, menopausal status, histological stage and markers of bone turnover were assessed by the research team.
The team found that the prevalence of osteoporosis was higher in primary biliary cirrhosis (32%) than in the control group (11%).
The investigators reported that osteoporosis was associated with older age, menopausal status, body mass index, longer primary biliary cirrhosis duration, advanced histological stage, high bilirubin and alkaline phosphatase, low albumin and prothrombin index.
Regression analysis was used by the researchers, which identified older age, higher Mayo risk score, lower body mass index and advanced histological stage but not menopause as the independent risk factors for osteoporosis.
Dr Guañabensa concludes, “Osteoporosis is more prevalent in women with primary biliary cirrhosis than in the general population.”
“Age and severity of the disease, but not menopausal status, are the main risk factors for osteoporosis in this liver disease.”