It is controversial as to whether the development of gastric cancer is influenced by Helicobacter pylori eradication.
If eradication itself influences the tumor morphology, this may affect the tumor discovery rate.
Dr Ito and colleagues from Japan investigated the morphological changes in the gastric neoplasm after Helicobacter pylori eradication.
The investigative team studied 37 patients with eradication therapy.
Higher expression of single-stranded deoxyribonucleic acid in gastric tumors do not correlate with the serum gastrin levels|
|Alimentary Pharmacology & Therapeutics|
After a 1-month follow-up, the team performed an endoscopic re-evaluation and the appearance was compared with first image.
The researchers resected all lesions endoscopically, and subjected the resections to histological assessment and to immunohistochemistry whereby serum gastrin levels were determined before and after eradication.
The team reported that 29 of 37 patients underwent successful eradication.
Furthermore, the researchers noted that the appearance of 11 lesions (33% of 33 lesions) became indistinct after successful eradication.
All lesions were of the superficial-elevated type and the height of the lesions decreased.
The investigators detected normal columnar epithelium over the neoplasm in 8 of the lesions.
Higher expression of single-stranded deoxyribonucleic acid in the deep area was characteristic in tumors with an indistinct appearance and the researchers found that these changes did not correlate with the serum gastrin levels.
Dr Ito concludes, “The morphology of the gastric neoplasm changes after eradication in the short-term, which may contribute to the decreased tumor discovery rate.”