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 23 May 2018

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News

Clincial trial: Retinol palmitate reduces radiation proctopathy

Retinol palmitate significantly reduces rectal symptoms of radiation proctopathy, possibly because of wound-healing effects, finds a report in Diseases of the Colon & Rectum.

News image

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This study was designed to determine whether oral retinol palmitate (vitamin A) can reduce the symptoms of radiation proctopathy.

Dr Ehrenpreis and colleagues from Chicago, America conducted a randomized, double-blind trial comparing retinol palmitate (10,000 IU by mouth for 90 days) to placebo.

The investigators enrolled patients with more than 6 months postpelvic radiotherapy that had symptoms as measured with the Radiation Proctopathy System Assessments Scale (n=19).

Symptoms were measured with the Radiation Proctopathy System Assessments Scale
Diseases of the Colon & Rectum

The research team randomised 10 to retinol palmitate and 9 to placebo.

Radiation Proctopathy System Assessments Scale scores before and every 30 days for 90 days were measured by the researchers.

The team crossed over 5 placebo nonresponders to the retinol palmitate for another 90 days.

The researchers defined response as a reduction in 2 or more symptoms by at least 2 Radiation Proctopathy System Assessments Scale points.

7 of 10 retinol palmitate patients responded, whereas 2 of 9 responded to placebo.

The research team noted that the mean pre-post-treatment change in Radiation Proctopathy System Assessments Scale in the retinol palmitate group was 11, and 2.5 in the placebo group.

In addition, the researchers observed that all 5 placebo nonresponders who were crossed over to treatment with retinal palmitate responded to treatment.

Dr Ehrenpreis concluded, “Retinol palmitate significantly reduced rectal symptoms of radiation proctopathy, perhaps because of wound-healing effects.”

”The current results can serve as the foundation for future trials examining retinol palmitate in the multi-institutional setting.”

Diseases of the Colon & Rectum 2005: 48(1): 1-8
25 February 2005

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