Dr Sunanda and colleagues undertook a study to understand the association between tobacco exposure and postoperative clinical recurrence in Crohn's disease patients.
In addition, the researchers aimed to quantify the time to clinical relapse following surgical resection.
It is well accepted that cigarette smoking has a negative impact on postoperative course in Crohn's disease.
However, the effect of smoking to hasten clinical recurrence has not been clearly delineated.
The research team reviewed medical records of patients undergoing surgical resection for medication-refractory disease within a 5-year period.
The researchers reviewed patients over a period of 250 weeks.
|69% of smokers vs 23% of nonsmokers had recurrent symptoms by the end of the observation period|
|Journal of Clinical Gastroenterology|
The research team then compared outcomes between smokers and nonsmokers and stratified these data by gender.
In total, the study included 59 patients.
The researchers found that 69% of smokers versus 23% of nonsmokers had recurrent symptoms by the end of the observation period.
In addition, the team noted that there was no difference in the mean ages, gender, disease location, use of postoperative medications, or number of postoperative visits.
Smoking was associated with an increased risk of clinical recurrence.
The researchers found that the time to clinical relapse for smokers was 130 weeks versus 234 weeks in nonsmokers.
Dr Sunanda concluded, "Smoking is associated with clinical recurrence of Crohn's disease, and the time to clinical recurrence in smokers is shorter."
"Strategies for smoking cessation are warranted".