Pyogenic liver abscess (PLA) is relatively uncommon in North America but it is associated with significant morbidity and mortality.
Dr Laupland and colleagues from Canada undertook a study in which they characterized the incidence and outcomes of PLA and the associated risk factors, in a nonselected population.
The researchers carried out the population-based surveillance in the Calgary Health Region (CHR) between April 1, 1999 and March 31, 2003.
The research team identified all adult CHR residents with PLA and reviewed all their charts.
In total, the researchers found that 71 CHR residents developed a PLA for an annual incidence of 2.3 per 100,000 population.
|3.3 per 100, 000 population of men vs 1.3 per 100,000 population of women were at risk of acquiring PLA|
|Clinical Gastroenterology and Hepatology|
In addition, the investigators noted that there was an increasing incidence of PLA with advancing age.
The researchers found that men were at much higher risk of acquiring a PLA as compared to women (3.3 vs 1.3 per 100,000, and this was observed across all age groups.
A number of comorbid conditions were associated with significantly higher risk for developing a PLA including liver transplantation patients, diabetics, and patients with a history of malignancy.
No other solid organ transplantation patient was at increased risk.
Dr Laupland commented, "All patients required admission to hospital and 10% of patients died in hospital, corresponding to a mortality rate of 0.22 per 100,000 population."
He added, "This study provides important data on the burden of PLA and identifies risk groups that might potentially benefit from preventive efforts."