Researchers from America designed a study in order to determine the frequency and the severity of pancreatitis after EUS-guided FNA of solid pancreatic masses.
The group conducted their survey using data from a number of centers that offer training in EUS in the United States.
The list of centers in which training in EUS is offered was obtained from the Web site of the American Society for Gastrointestinal Endoscopy.
Designated program directors were contacted via e-mail.
The group requested information about the number of EUS-guided FNA procedures performed for solid pancreatic masses, as well as the number of cases of post-procedure pancreatitis, and the method for tracking complications.
| EUS-guided FNA of solid pancreatic masses is infrequently associated with acute pancreatitis |
The researchers obtained technical details about the procedure, including the location of the mass, the type of fine needle used, the number of needle passes, and the nature of the lesion for each episode of pancreatitis.
19 of the 27 programs contacted returned the questionnaire (70%).
The researchers found that in total, 4909 EUS-guided FNAs of solid pancreatic masses were performed in these 19 centers over a mean of 4 years.
Pancreatitis occurred after 14 (0.29%) procedures.
At 2 centers in which data on complications were prospectively collected, the frequency of acute pancreatitis was 0.64%, suggesting that the frequency of pancreatitis in the retrospective cohort (0.26%) was under-reported.
The odds that cases of pancreatitis would be reported were 2.45 greater for the prospective compared with the retrospective cohort
The median duration of hospitalization for treatment of pancreatitis was 3 days.
The pancreatitis was classified as mild in 10 cases, moderate in 3, and severe in 1; 1 death (proximate cause, pulmonary embolism) occurred after the development of pancreatitis in a patient with multiple comorbid conditions.
The group concluded that EUS-guided FNA of solid pancreatic masses is infrequently associated with acute pancreatitis.
Dr Eloubeidi, speaking on behalf of the research group commented, "The procedure appears to be safe when performed by experienced endosonographers."