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 23 February 2018

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News

Prospective study into risk of malignancy in diagnosed celiac disease

Results from a 24 year prospective, population-based, cohort study into the risk of malignancy in patients diagnosed with celiac disease, have been published in October's issue of Alimentary Pharmacology and Therapeutics.

News image

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Recent evidence from studies of hospitalized and undiagnosed patients has shown that the risk of lymphoma for people with celiac disease may be lower than previously thought.

In addition, there have been no precise estimates of small bowel lymphoma risk due to a lack of population data.

T Card, J West and G.K.T. Holmes from Nottingham, England examined these and other malignant risks in a cohort of patients typical of those seen in routine clinical practice.

The researchers carried out a prospective cohort study of incident malignancy rates in patients with celiac disease in southern Derbyshire compared with general population figures.

The risk of non-Hodgkin's lymphoma in general or of the small bowel is lower than previously found from UK celiac cohorts
Alimentary Pharmacology and Therapeutics

The group looked at 5684 person years of follow-up and found that a total of 31 malignancies (excluding non-melanoma skin cancer) occurred in comparison with 30 expected.

They also found four non-Hodgkin's lymphomas of which one originated in small bowel.

GI malignancy occurred in nine (5.71 expected) and breast cancer in three (5.08 expected).

Dr Holmes concluded, "There is no increase in the risk of incident malignancy in this population."

He added, "The risk of non-Hodgkin's lymphoma in general or of the small bowel is lower than previously found from UK celiac cohorts."

Alimentary Pharmacology & Therapeutics;2004:20 (7):769
27 September 2004

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