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 25 May 2018

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News

Donor age, hepatitis C virus infection and 10-year liver graft histology

Donor age is a strong factor influencing the long-term histological outcome of liver grafts, find investigators in the latest issue of the Journal of Hepatology.

News image

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Factors influencing the long-term histological outcome of liver grafts are not known.

In this study, investigators from France assessed 10-year liver biopsies to identify the main factors influencing long-term graft histology.

They evaluated 270 of 423 patients who still had their first functional graft 10 years after liver transplantation.

All biopsy slides were reviewed by 2 pathologists.

The investigators found fibrosis in 54% of patients and ductopenia in 29%.

They determined that ductopenia was independently related to higher donor age.
Ductopenia was independently related to higher donor age.
Journal of Hepatology

The severity of fibrosis was influenced by hepatitis C virus (HCV) infection, hepatitis B virus (HBV) recurrence, and higher donor age.

The team found that 30% of biopsies showed minimal-change lesions which were associated with the absence of HCV or HBV infection, and lower donor age.

Dr Kinan Rifaia and colleagues concluded, "Post-transplant infection by HCV or HBV are main factors influencing the histological course of liver graft".

"Donor age was also a strong factor in HCV infected patients as well as in HCV-negative patients".

"This variable should be taken into account, particularly for candidate recipients with long life expectancy".

J Hepatol 2004; 41(3): 446-53
27 August 2004

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